The Global Regulator PhoU Positively Controls Growth and Butenyl-Spinosyn Biosynthesis in Saccharopolyspora pogona
Butenyl-spinosyn, a highly effective biological insecticide, is produced by Saccharopolyspora pogona.However, its application has been severely hampered by its low yield.Recent studies have shown that PhoU plays a pivotal role in regulating cell growth, secondary metabolite biosynthesis and intracellular phosphate levels.Nevertheless, the function